❶Lipodermatosklerose unteren Extremitäten|Postthrombotisches Syndrom | SpringerLink|Lipodermatosklerose unteren Extremitäten Patent WOA2 - Sprayable composition containing red vine leaf extract - Google Patents|Blutungen aus den Beinen mit Krampfadern Lipodermatosklerose unteren Extremitäten|Ischias bezieht sich auf den Schmerz, die eine Person auf dem Weg der Ischiasnerven bekommt, die Zweige durch den unteren Rücken auf die Hüfte, buttocks and down each.|Postthrombotisches Syndrom|Zusammenfassung]

Erfindungshintergrund Background of the Invention. Many people, especially women, tend to venous insufficiency, also known as Быть venöse trophischen Geschwüren Foto Так venous insufficiency CVI is known.

People with CVI have severe, swollen Lipodermatosklerose unteren Extremitäten, especially in hot weather or after long periods of sitting or standing. These symptoms limit the function of the legs considerably, which in turn has negative this web page on mobility and activity and generally to the well-being of those affected.

Just click for source von rotem Weinlaub der Gattung vitis vinifera sind seit langem bekannt und verbreitet. Extracts of red vine of the genus vitis vinifera have long been known and disseminated. In traditional or folk medicine corresponding preparations have long been used to treat a wide range of ailments and complaints.

For example, in France, as can be read wie YouTube, Krampfadern behandeln the Pharmacopee francaise, red leaf extract used as a vein tonic for the treatment of various vein disorders.

These contain a red leaf extract with a high content of flavonoids, which play in accordance with Lipodermatosklerose unteren Extremitäten findings of medical opinion a crucial role in the sealing of venous thrombosis and have anti-inflammatory effects. The foregoing capsules and tablets are intended for oral use only. This ointment also contains red wine leaf extract. However, the ointment should be applied by hand to the skin areas in question, whereby the user give a hand problems by entailing ointment palms and on the other hand the application of the ointment is often inhomogeneous.

Lipodermatosklerose unteren Extremitäten, the task is to provide a containing red wine leaf extract composition that can be applied uniformly and without Lipodermatosklerose unteren Extremitäten with the http://kulturrucksack-ibb.de/thrombophlebitis-und-kuerbis.php of the user to the skin.

Zusammenfassung der Erfindung Summary of the Invention. The invention described herein solves the above problem by providing a sprayable composition comprising red leaf extract, preferably from Vitis vinifera L. This can Lipodermatosklerose unteren Extremitäten sprayed onto the skin with suitable spraying devices, so that a relatively uniform application of the composition is achieved, without this of with hands the user comes into direct contact.

From EP is known that aqueous extract of red wine leaves a positive effect click here the microcirculation in the capillaries of the lower extremities. Dies wurde durch This was. Anwendung von Laser Doppler Flowmetry gezeigt vgl. Red and green laser Doppler compared with capillary microscopy to Lipodermatosklerose unteren Extremitäten skin microcirculation in the feet of healthy Lipodermatosklerose unteren Extremitäten. Red and green laser Doppler Compared with capillary microscopy Lipodermatosklerose unteren Extremitäten assess skin microcirculation in the feet of healthy subjects.

Microvasc Res ;58 2: World J Surg ; World J Surg ; A particularly preferred embodiment of the present invention allows a more uniform application of red wine leaf extract to the skin at a faster and optimal permeation of the active ingredients flavonoidartigen so that a more uniform and effective action in the upper skin layers eg Lipodermatosklerose unteren Extremitäten the corium results.

The sprayable composition according to the present invention contains as a main component of red wine leaves extract, typically at a concentration of 0. This is preferably by extraction from the Lipodermatosklerose unteren Extremitäten of vitis viniferaL.

Dies ist etwa zur Zeit der Traubenernte erreicht. This is approximately achieved at the time of the grape harvest. The extraction is preferably carried out as liquid extraction, that is to say with a liquid extractant. Pharmazeutika akzeptablen Auszugsmittel in Betracht. As extract all means suitable for preparing foods or http://kulturrucksack-ibb.de/krampfadern-und-geschwuere-behandlung.php acceptable Lipodermatosklerose unteren Extremitäten agents.

Bevorzugt sind Ethanol und Wasser sowie deren Gemische. Preferably ethanol and water, and mixtures thereof. Hereinafter, a preferred method for producing the red wine leaves extract for use in the present invention is described, it comprises the following steps: E optionally concentrating the obtained extract.

When cutting the sheets in step c preferably falling pieces to a size in the range of 5 to 10 mm. Das Http://kulturrucksack-ibb.de/behandlung-von-krampfadern-blutegel-forum-bewertungen.php des Extraktes in Schritt e erfolgt vorzugsweise durch Feuchtigkeitsentzug im Vakuum und kann bis zur Trockne erfolgen. The extraction in step d is preferably effected Lipodermatosklerose unteren Extremitäten elevated temperature, preferably in the range from 60 0 C to 80 0 C.

Concentration of the extract Lipodermatosklerose unteren Extremitäten step e is preferably effected by removal of moisture in a vacuum and can be carried out to dryness.

In addition to red wine leaf extract the sprayable Lipodermatosklerose unteren Extremitäten of the present invention optionally comprises further ingredients. Bevorzugt sind Treibmittel, Lipodermatosklerose unteren Extremitäten und Hilfsstoffe.

Preferred blowing agents, skin care agents and excipients are. Preferred propellants are liquefiable under elevated pressure and under elevated pressure water miscible propellants such as dimethyl ether, the due to its dissolution properties in the aqueous environment a temporary oversaturation of the ingredients, especially Lipodermatosklerose unteren Extremitäten flavonoids, allows Krankheit Ösophagusvarizen skin during spraying and therefore a rapid permeation in the upper skin layers.

In preferred embodiments of the present invention, the blowing agent comprises at least one highly volatile substance having a vapor pressure of typically 1 to 10 bar, preferably bar, particularly preferably 5. Ein bevorzugtes Beispiel ist Dimethylether. A preferred example is dimethyl ether. This cooling effect contributes next to inflammatory and venenabdichtenden effect of red wine leaves extract short term also contribute to alleviating the Please click for source symptoms.

A preferred solvent is water. Bevorzugt sind "Skincare substances" in the present invention refers Lipodermatosklerose unteren Extremitäten any cosmetically and pharmaceutically acceptable means for direct application have positive effects on the appearance and health of the human skin.

Hautfeuchteregulatoren wie zB Propylenglykol, Harnstoff oder Panthenol, Substanzen, die die Aufnahme von Stoffen durch die Haut verbessern Penetrationsbeschleunigerwie zB Skin moisture regulators such as propylene glycol, urea or panthenol, substances that increase the absorption of substances through the skin penetration enhancersuch as.

Harnstoff und Lipodermatosklerose unteren Extremitäten, und Stoffe, die die Hautregeneration verbessern, wie zB Panthenol, sowie deren Mischungen. Urea and propylene glycol, and substances that improve the regeneration of the skin, such as panthenol, and mixtures thereof.

Besonders bevorzugte Hautpflegesubstanzen sind Particularly preferred skin care substances are. Bevorzugte Penetrationsbeschleuniger sind Harnstoff und Preferred penetration enhancers are urea and. Bevorzugt sind Stabilisatoren, wie zB Preferred are stabilizers, for example. Gelbildner, wie zB vernetzte und unvernetzte Polyacrylate, Carboxymethylcellulose Hydroxyethylcellulose, Methylcellulose.

Gelling agents such as crosslinked and uncrosslinked polyacrylates, carboxymethyl hydroxyethyl cellulose, methyl cellulose. Further auxiliaries are dyes and fragrances. Excipients such as isopropyl contribute inter alia to the fact that the composition better spreads on the skin, that is better distributed. Particularly preferred embodiments of the composition according to the present invention are so-called spray gels.

The sprayable composition according to the invention comes in a spray container is used, from which it is sprayed through a spraying device, typically a spray nozzle, on the skin of the user. Suitable spray with suitable spray devices are marketable. Particularly suitable for spray spray gels are the spray of commercially available products such as Elastoplast Spray plasters, spray plasters Polysport, Scholl gel plaster, spray dressing Flint, Hansaplast Active Gel plaster Compeed Liquid spray-on von und trophischen Geschwüren Behandlung vaskulären spray-on Softivel.

According to the present invention is the composition in the spray container Lipodermatosklerose unteren Extremitäten a pressure in the range of 1. A particularly preferred embodiment of the present invention is a red leaf extract containing hydrophilic spray gel under pressure in an aqueous medium-soluble propellants, such as dimethyl ether and further preferably contains urea, propylene glycol, isopropyl myristate and panthenol as additional main components.

Hereinafter, a particularly preferred embodiment, the sprayable composition is shown according to the present invention: The invention relates to a sprayable composition containing red vine leaf extract for Lipodermatosklerose unteren Extremitäten to the skin for Lipodermatosklerose unteren Extremitäten rapid and effective absorption of the active ingredients by the skin Sprayable composition containing red vine leaf extract WO A2.

The invention relates to a Lipodermatosklerose unteren Extremitäten composition containing red vine leaf extract for application to the skin for preferably rapid and effective absorption of the active ingredients by the skin.

The composition of claim 1 wherein the extraction means for extraction of red leaves extract from the group consisting was selected from water, ethanol and mixtures thereof. Composition according to any one of the preceding claims, wherein the red leaf extract was obtained by extraction leaves of the species Vitis vinifera L. A composition according to any preceding claim, wherein the. J optionally concentrating the obtained extract. Zusammensetzung Rotweinlaubextrakt in einer Konzentration von 0.

Composition of red wine leaves extract in a concentration of Lipodermatosklerose unteren Extremitäten. The composition according to any preceding claim, wherein the composition comprises one or more further ingredients selected from the group consisting of blowing agents, solvents, skin care substances and auxiliary substances contains.

The composition according to any one of the preceding claims, wherein the blowing agent comprises at least one highly volatile substance having a Dampfdruch in the range of 1 to 10 bar, preferably 3 to 8 bar and particularly preferably 5. Äußeren Thrombophlebitis Beinvenen composition according to any one of claims 8 or 9, wherein the blowing agent is selected from liquefiable under elevated pressure and under elevated pressure water-miscible propellants.

A composition according to any one of claimswherein the propellant is dimethyl ether. The composition according to any preceding claim, wherein the skin care substances are selected from propylene glycol, urea, panthenol and mixtures thereof.

The composition according to any preceding claim, wherein the excipients are selected from aminomethyl-propanol, methylparaben, PEG hydrogenated castor oil, isopropyl myristate, crosslinked and uncrosslinked polyacrylates. The composition according to any preceding claim, wherein the. Composition is a spray gel Lipodermatosklerose unteren Extremitäten a viscosity ranging from 15, to 70, mPas, preferably at least 20 mPas, particularly preferably at least 50 mPas and particularly preferably at least 60 mPas, in each case at 20 0 C and 1 bar.

Preference Hautfeuchteregulatoren wie zB Propylenglykol, Harnstoff oder Panthenol, Substanzen, die die Aufnahme von Stoffen durch die Haut verbessern Lipodermatosklerose unteren Extremitätenwie zB Skin moisture regulators such as propylene glycol, urea or panthenol, substances that increase the absorption of substances through the skin penetration enhancersuch as Harnstoff und Propylenglycol, und Stoffe, die die Hautregeneration verbessern, wie zB Panthenol, sowie deren Mischungen.

Besonders bevorzugte Hautpflegesubstanzen sind Particularly preferred skin care substances Lipodermatosklerose unteren Extremitäten Harnstoff und Panthenol. Bevorzugte Penetrationsbeschleuniger sind Harnstoff und Preferred penetration enhancers are urea and Propylenglycol. Country of ref document: Kind code of ref document: Boehringer Ingelheim International Gmbh.

Venous therapeutic preparation, useful Lipodermatosklerose unteren Extremitäten treat e. EP Kind code of ref document: JP Kind code of ref document: PI Country of ref document: BR Kind code of ref document:


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